new glass magnetic separator in dodoma

an on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy - sciencedirect

an on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy - sciencedirect

A new planar bio-magnetic bead separator on a glass chip has been designed, fabricated and tested. The separator is composed of micromachined semi-encapsulated spiral electromagnets and fluid channels, which have been separately fabricated and then bonded. The device was tested with super-paramagnetic beads of mean diameter 1 m which were suspended in a buffered solution. When a DC current of 300 mA was applied to the inductor, the bio-magnetic beads were successfully separated on the electromagnets, showing a functional capability as a magnetic bead separator. To evaluate separation rate and capability, the inductance measurement method has been introduced and the inductance variation according to the separation rate has been characterized. Using this separator, cells or cell fragments and magnetic beads bonded with protein or enzyme suspended in bio-buffer solutions can be successfully separated from their suspensions, envisaging a filterless bio-separator.

optimizing colloidal dispersity of magnetic nanoparticles based on magnetic separation with magnetic nanowires array | springerlink

optimizing colloidal dispersity of magnetic nanoparticles based on magnetic separation with magnetic nanowires array | springerlink

Based on sharp geometry of Ni nanowires, we developed a novel high-gradient magnetic separator that was composed of a nanowires array and a uniform magnetic field. When suspension of magnetic nanoparticles (MNPs) flowed through it, the relatively large nanoparticles or clusters were removed from the suspension so that the size distribution can be improved. The separation resulted from magnetic force so that extra molecules or solvents were unnecessary to add. The performance was proved by scanned electron microscopy characterization and dynamic light scattering measurement. The improvement in magnetic colloidal dispersivity is important for the biomedical application of MNPs. Our results may also play a role in microfluidic application and nanoparticle-based detection.

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This work is supported by grants from the National Basic Research Program of China (2011CB933503, 2013CB733801) and the National Natural Science Foundation of China (NSFC, 21273002, 81100625). J. F. Sun is also thankful to the supports from the Natural Science Foundation of Jiangsu Province (BK2011590), QingLan Project of Jiangsu Province and the special fund for the top doctoral thesis of Chinese Education Ministry (201174) and the Fundamental Research Funds for the Central Universities (Southeast grant for young scholars).

State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, Peoples Republic of China

Sun, J., He, M., Liu, X. et al. Optimizing colloidal dispersity of magnetic nanoparticles based on magnetic separation with magnetic nanowires array. Appl. Phys. A 118, 569577 (2015). https://doi.org/10.1007/s00339-014-8758-8

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