pharmaceutical ball mill manufacturers

pharma bead mills | dyno-mill pharma | wab group

pharma bead mills | dyno-mill pharma | wab group

Particle Size Reduction of Active Pharmaceutical Ingredients (API ). The wet milling technology of WAB allows for effectively reducing the particle size of API and excipients. With the DYNO-MILL PHARMA equipment, coarse particles are milled to establish the required particle size distribution. The DYNO-MILL PHARMA equipment line is capable of mechanical Micronization and Nanosization at current Good Manufacturing Practice (cGMP) level protocols. Realised through semi-automatic or fully automatic control units, and the 21 CFR part 11 compliant WAB SCADA-System. In addition, selected DYNO-MILL PHARMA units are available with Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) functionality. WAB supports its customers with great attention to detail from the initial definition of the User Requirement Specification (URS) throughout the IQ/OQ.

The Pharmaceutical Manufacturer first prepares a pumpable suspension of the solid API in a liquid medium. This raw suspension usually has a very wide particle size distribution and contains a high percentage of coarse particles. The coarse particles are mainly formed by aggregated and agglomerated API material. The main task of the DYNO-MILL PHARMA equipment is to disperse the aggregates and agglomerates to the desired particle size distribution. With the many stages and requirements in the API development process, a broad range of solutions is a helpful support. WAB has decades of experience in the Pharmaceutical Industry and a proven spectrum of equipment to supports its global customer base.DYNO-MILL PHARMA wet milling equipment:

ball mill, ball grinding mill - all industrial manufacturers - videos - page 2

ball mill, ball grinding mill - all industrial manufacturers - videos - page 2

RAPID MILL WITH PLANETARY DRIVE, "MAGELLANO" SERIES, MOD. MAG3000/C WITH 4 ROTATING UNIT The requirement of some laboratories in the ceramic industry to be able to rapidly grind large frit quantities, led Ceramic ...

... Convenient in maintenance. Working Principle The Ball mill 9001800 can be divided into lattice type and overflow type according to different beneficiation methods, and this machine is two lattice-type ...

High operational reliability, stable performance, simple structure and easy maintenance. Model with speed controller available.(Model : J-BM1-S) Displays realtime operation speed utilizing rpm meter.(Model : J-BM1-S)

The Laboratory Ball Mill is primarily designed for grinding pigments and cement. The material is ground at a specific speed for a specific period using a specific quantity of grinding steel balls. ...

ball mill | ball mills | wet & dry grinding | dove

ball mill | ball mills | wet & dry grinding | dove

DOVE Ball Mills are supplied in a wide variety of capacities and specifications. DOVE small Ball Mills designed for laboratories ball milling process are supplied in 4 models, capacity range of (200g/h-1000 g/h). For small to large scale operations, DOVE Ball Mills are supplied in 17 models, capacity range of (0.3 TPH 80 TPH).

With over 50 years experience in Grinding Mill Machine fabrication, DOVE Ball Mills as critical component of DOVE Crushing plants are designed with highest quality of material for long life and minimum maintenance, to grind ores to 35 mesh or finer.

DOVE Grinding Mills are supplied in a wide range of capacities and specifications, for reliable and effective grinding, size reduction applications and for diverse applications of either dry or wet ore.

DOVE Ball Mills have extended history in the Mining and Mineral Processing Industry, Construction, Solid Waste Processing, Food Processing Industry, Chemical and Biochemical Industry, for Pyrotechnics and Ceramics.

DOVE Ball Mills are designed to operate with various types of grinding media, including Ball Mills Balls. DOVE supply Steel Balls in Various sizes and specifications. Cast Iron steel Balls, Forged grinding steel balls, High Chrome cast steel bars, with hardness of 60-68 HRC. We also supply Grinding Cylpebs with surface hard ness of 60-68 HRC, and grinding Rod with surface hardness of 55-60 HRC.

DOVE Ball Mills are made of high grade cast and carbon steel for extra strength, long and trouble-free operations. The inner lining plate designed with high manganese steel for long life and minimum wear off.

DOVE Ball Mill can be integrated in a Complete Plant designed by DOVE Engineering Services, provided for our Clients application and supplied with all components of the plant for efficient processing, smooth operation and efficient integration with the balance of the Processing Plant.

DOVE Ball mills, also known as Grinding mill, Mining mill, Pebble mill, Ball & Pebble mill, is an important machinery in the mining and various other industries, which would require grinding different material.

They are highly efficient Grinding mill machines, designed for grinding applications, where fine material is required. DOVE Ball Mills are used in supplied and applicable for wet and dry grinding applications within the following branches of industries:

DOVE ball mills is a rotating horizontal cylinder that tumbles the material to grind with a certain media. The standard media that we use in our ball milling process are the steel grinding balls, however depending on the specific application, we can configure the grinding mill with different media.

DOVE supplies various types and sizes of Ball Mill Balls, including; Cast Iron steel Balls, Forged grinding steel balls, High Chrome cast steel bars, with surface hardness of 60-68 HRC. DOVE Ball Mills achieves size reduction by impact and attrition. When the cylinder rotates, the balls are dragged to almost the top of the shell, and from there, they fall unto the material, which lead to the material breaking due to the impact.

DOVE Ball Mills are used in hard rock mineral processing plants as an ore-dressing step to grind the rocks into fine powder size, liberating the mineral particles from the rocks. This will ensure that the ore is well prepared for the next stage of processing and optimize the recovery of the minerals.

DOVE ball mill is integrated and used in DOVE Portable and Semi-Stationary Hard Rock plants (Hard Rock processing plants) to efficiently grind the ore from primary deposit until the liberation size of valuable minerals is reached. DOVE ball mill is the key grinding equipment after material is crushed. It is used to grind and blend bulk material into powder form using different sized balls. The working principle is simple, impact and attrition size reduction take place as the ball drops from near the top of the rotating hollow cylindrical shell of the Ball Mill. The output materials will be feed to the processing and recovery machines.

DOVE Ball Mills are deigned for either wet or dry grinding of materials, in various models, and in accordance to the processing and the crushing plant design, to cater to the liberation size of the minerals and the hardness of the ore.

DOVE supplies two different kinds of ball mills Grate type, and Overfall type. The difference between the two type is according to their ways of discharging material, and the plant flow design specifications.

The Grinding Balls will grind the material into powder size of 20 to 75 micron. In mining operations, this will allow for the liberation of gold and other precious metals that are hosted by the rocks. Many types of grinding media are suitable for use in a ball mill, each material having its own specific properties, specification and advantages.

Media Size: The grinding media particles should be substantially larger than the largest pieces of final material after grinding. The smaller the media particles, the smaller the particle size of the final product.

Composition: Each ball mill application has different requirements. Some of these requirements are relates to the grinding media being in the finished product, while others are based on how the media will react with the material being milled. Therefor, grinding media selection plays major factor on the final milled product.

Contamination: In certain grinding mill process, low contamination is important, the grinding media may be selected for ease of separation from the finished product, for example steel dust produced from steel balls can be magnetically separated from non-ferrous products. An alternative to separation is to use media of the same material as the product being milled.

Corrosive:Certain type of media, such as steel balls, may react with corrosive materials. For this reason, stainless steel balls, or ceramic balls, and flint grinding media may each be used when corrosive substances are present during grinding.

micronization in the pharmaceutical industry

micronization in the pharmaceutical industry

Micronization is the process of reducing a bulk solid materials particle size to the micron or submicron level. This article discusses dry powder milling techniques and their effectiveness for micronization, specifically in the pharmaceutical industry. The article looks at how mechanical, ball, and jet mills stack up against each other.

Studies have linked micronization with the increased bioavailability of active pharmaceutical ingredients since the early 1980s.1 Simply put, finer particles increase a materials surface area, which increases bioavailability, especially in poorly soluble materials.2 Since then, considerable research has evaluated the effects of different types of milling on micronization. These studies, however, typically include wet-milling techniques, which skew the findings. While wet milling does tend to create finer particles, it also increases costs and steps and adds many variables that dry milling doesnt include.

Mechanical mills. Hammermills or pin mills are usually the first mills that pharmaceuticals, cosmetics, or sanitary materials manufacturers consider when evaluating techniques for particle size reduction. Basically, these mills have hammers or pins that rotate and strike the material particles. The design, as well as the number of pins or hammers, varies with the application. Well-designed, high-speed mechanical mills can grind some friable materials to a low-micron size. Practically speaking, a commercial hammermill can obtain a particle size of 200 mesh (74 microns), with a typical mid-range particle size of 80 mesh (177 microns).

Equipment wear and material contamination, however, are serious problems when using a high-speed mechanical mill, as is attritional heat. Contamination is an issue in most product applications and can be very acute in pharmaceutical manufacturing. Ingredients can seriously erode hammermills, adding metallic contamination to the product. Bulk solids materials that degrade with heat or have low melting temperatures also are a problem for hammermills because the mills generate heat, typically reaching temperatures above 90C (194F). Materials such as active pharmaceutical ingredients and pharmaceutical excipients that have lower melting temperatures or are prone to heat degradation are usually not great candidates for mechanical milling.

Ball mills. Ball mills tend to be the least expensive and most obvious micronization option, especially for pharmaceutical research and development. The use of ball milling as a micronization technique for enhancing drug solubility has been well supported by literature as far back as the 1970s.

Ball mills micronize material by agitating it in a vessel using steel or ceramic balls or other media. Apart from ball millings comminution function, the technique also serves as an intensive mixing technique capable of producing co-ground, pharmaceutical-excipient mixtures comprising amorphous drug forms mixed with suitable hydrophilic excipients at the molecular level.3

Milling is always a function of residence time in the mill, but ball mills are especially sensitive to residence time and can create long batch processes. Ball mills equipped with a classifier can produce a finely sized product, but the particle size distribution (PSD) tends to be very wide. By the time this type of mill achieves the correct average particle size, the number of fines is usually too high (above 10 percent). Mill suppliers can line ball mills with ceramics to reduce contamination from abrasive materials, but mill media wear is constant, which also can contaminate a product.

Jet mills. Until the introduction of jet mills in 1936, dry grinding in the subsieve range of 625 mesh (20 microns) to 2,500 mesh (5 microns) was impractical. To create fine particles with a narrow PSD, manufacturers previously had to mill the material, sieve out the oversized particles, and re-mill. The process was long, expensive, and inefficient.

Jet mills can mill materials to single-digit micron particle sizes in a single pass, increasing yield and operational efficiencies, as shown in the graphs in Figure 1. Figure 1a. shows ball-milled materials PSD, while 1b. shows a jet-milled material. In this micronization method, the mill injects high-velocity, compressed air into a chamber where a rate-controlled feeder adds the starting raw materials. As the particles enter the airstream, they accelerate and collide with each other and the milling chambers walls at high velocities. Particle size reduction occurs through a combination of impact and attrition. Impacts arise from the collisions between the rapidly moving particles and between the particles and the wall of the milling chamber. Attrition occurs at particle surfaces as particles move rapidly against each other, resulting in shear force that can break up the particles.

In addition to creating fine particles with a narrow PSD, jet mills have other qualitative advantages over ball and mechanical mills. A jet mill cools the temperature of the air leaving the jets to about -200F due to the Joule-Thomson effect, and the product leaves the mill no warmer than the air used for the grinding. The heat generated by the friction from particle-to-particle and particle-to-wall collisions is offset by the cooling effect of the expanding air. This allows for dry milling of a wider range of materials, especially more delicate, heat-sensitive materials.

A jet mill allows the pharmaceutical manufacturer to grind a friable or crystalline material to an average particle size of 1 to 10 microns and to classify it in a very narrow particle size range at the same time. The mill has no moving parts to wear out or generate heat and no screens to plug or be punctured. Jet mills also develop no attritional heat because of the cooling effect of the jets.

One of the most important characteristics of a jet-milled product is the huge increase in surface area. Milling a material thats 30 mesh (595 microns) down to 2,500 mesh (5 microns) results in 1,643,000 times the number of particles and a surface area thats 118 times greater. This allows for faster chemical reaction times and improved pharmaceutical ingredient performance.

The increased emphasis on PSD affects high-potency manufacturing as well. For example, the increased specific surface area of finely ground active pharmaceutical ingredients results in higher bioavailability, making particle-size control and distribution key performance parameters.4

In one study of micronization processes for four drug products, J.C. Chaumeil found that digestive absorption of poorly soluble drugs depended on their rate of dissolution and that decreasing the particle size using fine-grinding mills, especially jet mills, improved that rate.2 Using Chaumeils study as a baseline, Muller et al. reported an increase of 50 percent in the solubility of an insoluble antimicrobial compound when the particle size was reduced from 2.4 m to 800 or 300 nm.5

One of the important secondary uses for jet mills is blending powders. The operator can feed two or more streams of material into a jet mill at the same time, resulting in a homogeneous blend at the output. As stated above, pharmaceutical manufacturers have long used ball mills for blending while milling; however, co-milling in jet-milling environments has delivered consistent, homogeneous, and tighter PSD results.

Finally, de-agglomeration and polishing of sharp edges is another jet mill use. The former application applies generally to spray-dried or atomized materials, which are very popular in the solid dosage manufacturing process, usually after wet milling. This step usually creates a better-flowing product and further increases surface area, improving bioavailability. The latter application tends to interest R&D personnel in pharmaceutical manufacturing for testing different form factors of both active pharmaceutical ingredients and excipients during formulation. Generally, both of these require a reduction in air pressure.

Fred Surville (312-502-5818) is vice president of sales and marketing for Jet Pulverizer. After receiving his BA and MS in international affairs from Florida State University, he developed his technology sales and marketing skills on projects ranging from waste-to-energy, industrial zero-waste initiatives, and data center power and cooling. He recently received his MBA from the University of Chicago Booth School of Business.

ball mill: operating principles, components, uses, advantages and

ball mill: operating principles, components, uses, advantages and

A ball mill also known as pebble mill or tumbling mill is a milling machine that consists of a hallow cylinder containing balls; mounted on a metallic frame such that it can be rotated along its longitudinal axis. The balls which could be of different diameter occupy 30 50 % of the mill volume and its size depends on the feed and mill size. The large balls tend to break down the coarse feed materials and the smaller balls help to form fine product by reducing void spaces between the balls. Ball mills grind material by impact and attrition.

Several types of ball mills exist. They differ to an extent in their operating principle. They also differ in their maximum capacity of the milling vessel, ranging from 0.010 liters for planetary ball mills, mixer mills, or vibration ball mills to several 100 liters for horizontal rolling ball mills.

Im grateful for the information about using a ball mill for pharmaceutical products as it produces very fine powder. My friend is working for a pharmaceutical company and this is a good article to share with her. Its good to know that ball mills are suitable for milling toxic materials since they can be used in a completely enclosed for. Thanks for the tips!

pharma machinery manufacturer, pharmaceutical machinery manufacturer

pharma machinery manufacturer, pharmaceutical machinery manufacturer

Shakti Pharma Tech is a well established pharmaceutical lab machinery manufacturer and exporter. We are renowned for offering highly advanced machinery to serve the needs of the pharmaceutical industry, pharmaceutical colleges, and universities, along with research & developments (R &D) purposes.

ball mill - all medical device manufacturers - videos

ball mill - all medical device manufacturers - videos

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... range and an absolutely secure automatic clamping of the bowls by the mill. Your advantages with the Planetary Mill PULVERISETTE 5 premium line: - Extra strong 2.2 kW drive power and extremely ...

... can also use Planetary Mills for mixing and homogenising emulsions and pastes or for mechanical activation and alloying in materials research. The comminution takes place primarily through the high-energy impact of ...

... and grinding balls to separate from the inner wall of the grinding bowl. The grinding balls then cross the bowl at high speed and further grind the sample material by impact against the opposite bowl ...

BeadBlaster 96 Ball Mill Homogenizer Wet, dry or cryogrinding Accepts a variety of tubes, plates and jars Large, digital touch screen control panel See-though safety lid Specifications Speed ...

Vertical Planetary Ball Mill(Square Model) Features: * 3D curve shape design. * Special gear with low noise. Model BKBM-V2S Capacity 2L Volume of Each Capacity 50~500ml Pot Quantity ...

Light Horizontal Planetary Ball Mill 1.Horizontal structure of grinding pots. 2.Special gear with low noise. Model BKBM-H2L Capacity 2L Volume of Each Capacity 50~500ml Pot Quantity ...

... the operator is lightened Principle A small steel ball (or zirconia ball) is added to a grinding tank or centrifuge tube, and the grinding tank or adapter is vertically vibrating. The ball ...

For medium- to high-throughput sample disruption for molecular analysis Convenient and secure disruption process Adapter sets optimized for high-throughput disruption Wide range of accessories available Reproducible results with ...

The Emax is an entirely new type of ball mill for high energy milling. The unique combination of high friction and impact results in extremely fine particles within the shortest amount of time. The ...

Ball Mill J-BM1 and J-BM1-S are physical and chemical experiment apparatuses commonly used in laboratories, industrial research facilities and examining rooms of general hospitals. They have high operational ...

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